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Cheson BD, Keating MJ, and Plunkett W (eds.).
ANSWERS Nucleoside Analogs in Cancer Therapy. New York:
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656 VI CHEMOTHERAPY
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Case Study Treatment of Leukemic Meningitis
15-year-old girl moves into your neighborhood ANSWER: Immediately arrange for an evaluation of
Aand makes an appointment to see you. She is the CSF. If the CSF reveals leukemic cells, you can
being treated for acute lymphoblastic leukemia. She consider administering methotrexate 12 mg in-
tells you that she has been doing well, but recently trathecally every day for 4 days. With such a regi-
she has had frequent severe headaches, and her men, subsequent evaluations of the CSF often indi-
mother said she has stumbled a couple of times dur- cate no leukemic cells present. The headaches and
ing the past week for no apparent reason. She is be- balance problems typically disappear. Six months
ing treated with cytarabine. If leukemic meningitis later, most patients show no evidence of leukemia.
is suspected, what should be done next?
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